HPP593

Overview

HPP593 is a functionally selective peroxisome proliferator-activated receptor delta (“PPAR-delta”) agonist that does not exhibit off-target activity. In December 2017, we licensed worldwide rights to develop and commercialize HPP593 to Reneo Pharmaceuticals

Clinical Trials

Reneo is conducting an open label study in the United Kingdom to determine the safety and tolerability of REN001 in patients with primary mitochondrial myopathies. For additional information on the study, refer to NCT03862846 at Clinicaltrials.gov. 

Reneo is also conducting an open label study in the United States to determine the safety and tolerability of REN001 in patients with fatty acid oxidation disorders. For additional information on the study, refer to NCT03833128 at Clinicaltrials.gov. 

Reneo is also conducting an open label study in the United Kingdom and Spain to determine the safety and tolerability of REN001 in patients with McArdle disease.

HPP593 has completed three phase 1 studies of up to 28 days in duration. HPP593 was well tolerated at all doses tested.

Mechanism of Action

PPAR-delta, a member of the nuclear regulatory superfamily of ligand-activating transcriptional regulators, is expressed in most metabolically active tissues throughout the body. Studies in mice have shown that PPAR-delta agonists induce genes related to mitochondrial biogenesis. PPAR-delta activation by agonists also reduces blood glucose, improves insulin insensitivity and regulates inflammation.